OGT
Description
The OGT (O-linked N-acetylglucosamine (GlcNAc) transferase) is a protein-coding gene located on chromosome X.
OGT may refer to:
OGT (O-GlcNAc transferase) is an enzyme that catalyzes the transfer of a single N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins, modifying them with a beta-linked N-acetylglucosamine (O-GlcNAc). This glycosylation process affects a wide range of cellular processes, including insulin resistance, glycolysis regulation, chromatin structure, circadian rhythm, autophagy, and mTORC1 signaling. OGT regulates the activity and stability of various proteins by glycosylating them, including histone H2B, AKT1, AMPK, ATG4B, CAPRIN1, EZH2, FNIP1, GSDMD, KRT7, LMNA, LMNB1, LMNB2, RPTOR, HOXA1, PFKL, KMT2E/MLL5, MAPT/TAU, TET2, RBL2, RET, NOD2, and HCFC1. OGT also interacts with various proteins, including SIN3A, TET1, TET2, TET3, ATXN10, NSD2, PROSER1, USP7, and Tax, affecting transcriptional repression, chromatin remodeling, and stability of target proteins. OGT exists as a monomer or oligomer in different cellular states and is part of several protein complexes, including the NSL complex, THAP1/THAP3-HCFC1-OGT complex, and a complex containing KMT2E/MLL5, OGT, and USP7.
OGT is also known as HINCUT-1, HRNT1, MRX106, O-GLCNAC, OGT1, XLID106.
