KLF11
Description
The KLF11 (KLF transcription factor 11) is a protein-coding gene located on chromosome 2.
KLF11 is a zinc finger transcription factor in the Krüppel-like factor (KLF) family, derived from mesoderm. It binds to SP1-like GC-rich sequences in epsilon and gamma globin gene promoters, inhibiting cellular growth and causing apoptosis. KLF11 is involved in cellular inflammation and differentiation, making it essential for early embryonic development. This transcription factor binds to promoters of genes involved in cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism, specifically pancreatic beta cell function. Defects in KLF11 affect glucose metabolism, insulin transcription, insulin processing, and insulin secretion, leading to type 2 diabetes in adults and maturity-onset diabetes of the young type 7. These types of diabetes are caused by KLF11 interacting with co-repressors in the pancreatic islet beta cells. KLF11 has recently been shown to be involved in endometriosis, regulating the expression of extracellular matrix genes. Its absence in extracellular matrix genes created a more fibrogenic response by the tissue, as demonstrated by a 'knockout' model.
KLF11 is also known as FKLF, FKLF1, MODY7, TIEG2, Tieg3.
