KIF22
Description
The KIF22 (kinesin family member 22) is a protein-coding gene located on chromosome 16.
KIF22, a human gene, encodes a protein belonging to the kinesin-like protein family. This protein family plays a critical role in intracellular organelle transport and chromosome movement during cell division. The C-terminal portion of KIF22 is known to bind DNA. Studies using the Xenopus homolog suggest that KIF22 is essential for chromosome alignment during metaphase and their stability. KIF22 is known to interact with the protein SIAH1. Mutations in the KIF22 gene have been linked to developmental disorders such as Spondyloepimetaphyseal dysplasia with joint laxity.
KIF22, a kinesin family member, participates in spindle formation and chromosome movement during mitosis and meiosis. It binds to both microtubules and DNA, demonstrating its role in chromosome congression in cells lacking NDC80 protein.
KIF22 is also known as A-328A3.2, KID, KNSL4, OBP, OBP-1, OBP-2, SEMDJL2.
Associated Diseases
- Spondyloepimetaphyseal dysplasia with joint laxity, type 2
- Spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type
