KANK1
Description
The KANK1 (KN motif and ankyrin repeat domains 1) is a protein-coding gene located on chromosome 9.
KANK1 is involved in regulating the cytoskeleton by controlling actin polymerization. It inhibits the formation of actin fibers and cell migration, likely through its interaction with 14-3-3 adapter proteins and inhibition of RhoA activity, which is regulated by PI3K/Akt signaling. KANK1 also inhibits the formation of lamellipodia, but not filopodia, by blocking BAIAP2 association with activated RAC1. Additionally, KANK1 inhibits fibronectin-mediated cell spreading, partially through BAIAP2, and suppresses neurite outgrowth. In wound healing, KANK1 is crucial for establishing and maintaining cell polarity during directed cell movement. Within the nucleus, KANK1 participates in beta-catenin-dependent activation of transcription. Furthermore, KANK1 acts as a potential tumor suppressor for renal cell carcinoma and regulates Rac signaling pathways.
KANK1 is also known as ANKRD15, CPSQ2, KANK.
