HCN1
Description
The HCN1 (hyperpolarization activated cyclic nucleotide gated potassium channel 1) is a protein-coding gene located on chromosome 5.
HCN1, or Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, is a protein encoded by the HCN1 gene. HCN1 channels contribute to spontaneous rhythmic activity in both the heart and brain. They are found in the sinoatrial node, neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion, and brainstem. HCN1 is inhibited by ketamine, propofol, isoflurane, and sevoflurane. It interacts with HCN2. De novo mutations in HCN1 can cause epilepsy.
HCN1 is a hyperpolarization-activated ion channel that exhibits weak selectivity for potassium over sodium ions. It contributes to the native pacemaker currents in the heart (If) and in neurons (Ih). HCN1 may also mediate responses to sour stimuli.
HCN1 is also known as BCNG-1, BCNG1, DEE24, EIEE24, GEFSP10, HAC-2.
Associated Diseases
- Generalized epilepsy with febrile seizures plus, type 10
- Non-specific early-onset epileptic encephalopathy
- Generalized epilepsy with febrile seizures-plus
- Epileptic encephalopathy, early infantile, 24
