DPF2
Description
The DPF2 (double PHD fingers 2) is a protein-coding gene located on chromosome 11.
DPF2 (Zinc finger protein ubi-d4) is a protein that plays a critical role in cellular processes, particularly in the regulation of gene expression and apoptosis. It contains a zinc finger-like structural motif and functions as a transcription factor. DPF2 is essential for the apoptotic response following the deprivation of survival factors and is involved in regulating rapid cell growth and turnover in hematopoietic cells. This gene is considered a candidate gene for multiple endocrine neoplasia type I, a rare condition involving multiple tumors in the parathyroid, pancreas, and pituitary gland.
DPF2 plays a crucial role in regulating gene expression by binding to modified histone proteins H3 and H4. It acts as a negative regulator of myeloid differentiation in hematopoietic progenitor cells. Additionally, it might be involved in the development and maturation of lymphoid cells. Furthermore, DPF2 participates in the regulation of the non-canonical NF-kappa-B pathway.
DPF2 is also known as CSS7, REQ, SMARCG2, UBID4, ubi-d4.
