CD96
Description
The CD96 (CD96 molecule) is a protein-coding gene located on chromosome 3.
CD96, also known as Tactile (T cell activation, increased late expression), is a protein encoded by the CD96 gene in humans. It is a receptor protein expressed on T cells and NK cells, sharing sequence similarity with CD226 (DNAM-1). CD96 belongs to the immunoglobulin superfamily and is a type I membrane protein. It may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the immune response and may also function in antigen presentation. Alternative splicing occurs at this locus, resulting in two transcript variants encoding distinct isoforms. CD96 is a transmembrane glycoprotein with three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. Its main ligand is CD155. CD96 has approximately 20% homology with CD226 and competes for binding to CD155 with CD226.
CD96 is also known as TACTILE.
