BTRC
Description
The BTRC (beta-transducin repeat containing E3 ubiquitin protein ligase) is a protein-coding gene located on chromosome 10.
BTRC is a human gene that encodes a protein involved in protein degradation. It is a component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex, which targets specific proteins for degradation within the proteasome. BTRC recognizes and binds to phosphorylated target proteins, facilitating their ubiquitination and subsequent degradation. This process is essential for regulating various cellular processes, including cell cycle control, signal transduction, and transcription.
BTRC, also known as F-box/WD repeat-containing protein 1A, is a key component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. This complex plays a vital role in targeting specific proteins for degradation within the proteasome. BTRC recognizes and binds to phosphorylated target proteins, facilitating their ubiquitination and subsequent degradation. This process is crucial for regulating various cellular processes. For instance, BTRC regulates the Wnt signaling pathway by mediating the ubiquitination of CTNNB1 (beta-catenin). It also controls the NF-kappa-B signaling pathway by mediating the ubiquitination of NFKB1 (p105), NFKBIA (IκBα), NFKBIB (IκBβ), and NFKBIE (IκBε). Furthermore, BTRC regulates the cell cycle by mediating the ubiquitination of CDC25A, and it contributes to the circadian rhythm by mediating the ubiquitination of PER1 and PER2. In addition, BTRC regulates mTORC1 signaling by mediating the ubiquitination of DEPTOR, TFE3, and MITF. Notably, BTRC interacts with a diverse range of proteins, including SKP1, CUL1, RBX1, CTNNB1, NFKB1, NFKBIA, NFKBIB, NFKBIE, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1, CEP68, REST, KLF4, and many others. Through these interactions, BTRC modulates a wide array of cellular processes, highlighting its critical role in maintaining cellular homeostasis.
BTRC is also known as BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP.
