AKT2
Description
The AKT2 gene provides instructions for making a protein called AKT2, a key player in cellular processes such as growth, survival, and metabolism. It is a member of the AKT family of serine/threonine kinases, which act as molecular switches that control a wide range of cellular activities. AKT2 is activated by various signaling pathways, including those triggered by growth factors, hormones, and nutrient availability. This activation leads to phosphorylation of downstream targets, ultimately influencing cell growth, proliferation, and metabolism.
Associated Diseases
- Cancer (breast, prostate, lung, colon, etc.): Mutations in AKT2 can lead to increased cell growth and survival, contributing to cancer development.
- Diabetes: AKT2 plays a role in insulin signaling, and mutations can disrupt insulin sensitivity, contributing to type 2 diabetes.
- Metabolic disorders: AKT2 is involved in lipid metabolism, and dysregulation can contribute to obesity and other metabolic disorders.
- Neurological disorders: Emerging evidence suggests a role for AKT2 in certain neurological disorders, though further research is needed.
Did you know?
AKT2 has been nicknamed the "cell survival gene" due to its crucial role in protecting cells from programmed death.
