AKR1C4
Description
The AKR1C4 gene encodes for aldo-keto reductase 1C4, an enzyme involved in the reduction of various carbonyl compounds, including steroids, prostaglandins, and xenobiotics. AKR1C4 plays a crucial role in hormone metabolism, inflammation, and detoxification processes. Its expression is highly variable across tissues and is influenced by various factors, including sex hormones and environmental exposures. Variations in AKR1C4 activity have been linked to several diseases, including prostate cancer, breast cancer, and diabetes.
Associated Diseases
Did you know?
AKR1C4 expression is significantly higher in women than men, particularly in the breast and uterus.
