UBE3B : ubiquitin protein ligase E3B
Description
The UBE3B (ubiquitin protein ligase E3B) is a protein-coding gene located on chromosome 12.
The UBE3B gene provides instructions for making a protein that plays a vital role in the ubiquitin-proteasome system, the cellular machinery responsible for breaking down unwanted proteins. The UBE3B protein, an E3 ubiquitin ligase, functions by tagging damaged and excess proteins with ubiquitin molecules, signaling to proteasomes for their degradation. The ubiquitin-proteasome system acts as the cell's quality control system, removing damaged, misfolded, and excess proteins, thus regulating critical cellular activities like cell division and growth. While the specific proteins targeted by UBE3B complexes remain unidentified, research suggests its involvement in the nervous system, digestive tract, respiratory system, and various other organs and tissues from birth through adulthood.
UBE3B, an E3 ubiquitin ligase, receives ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester bond. Subsequently, it directly transfers the ubiquitin molecule to specific target proteins.
UBE3B is also known as BPIDS, KOS.
