TTC26
Description
The TTC26 gene, located on chromosome 10, encodes a protein that plays a crucial role in various cellular processes. This protein, known as tetratricopeptide repeat domain 26, is involved in protein-protein interactions, contributing to the regulation of cellular signaling pathways, protein trafficking, and organelle biogenesis. TTC26's diverse functions highlight its importance in maintaining cellular homeostasis.
Associated Diseases
- Hereditary spastic paraplegia (HSP): Mutations in TTC26 have been linked to several types of HSP, characterized by progressive lower limb weakness and spasticity.
- Neurodevelopmental disorders: Emerging evidence suggests a potential role of TTC26 in neurodevelopmental disorders, although further research is needed to establish a definitive link.
- Mitochondrial dysfunction: TTC26's involvement in protein trafficking and organelle biogenesis suggests a potential connection to mitochondrial dysfunction and associated diseases.
- Cancer: Some studies indicate a possible association between TTC26 variations and certain types of cancer, though more research is required to understand the underlying mechanisms.
Did you know?
The TTC26 protein contains multiple tetratricopeptide repeat (TPR) domains, which act like protein-binding modules, allowing the protein to interact with a wide range of other proteins.
