TOP3A
Description
TOP3A, also known as topoisomerase III alpha, is a gene that encodes a DNA topoisomerase enzyme. Topoisomerases are crucial for managing the complex structure of DNA, playing a vital role in processes like DNA replication, transcription, and repair. TOP3A specifically acts on DNA supercoiling, a phenomenon that can hinder these processes. By altering DNA topology, TOP3A helps maintain genomic integrity and regulate gene expression. The gene is highly conserved across species, indicating its essential function in cellular life.
Associated Diseases
- Cancer (various types): TOP3A mutations have been linked to several cancers, including leukemia, lymphoma, and breast cancer. Altered TOP3A activity can contribute to uncontrolled cell growth and tumor development.
- Developmental Disorders: Mutations in TOP3A can cause developmental problems, though this is less commonly reported.
- Neurological Conditions: Some research suggests potential links between TOP3A dysregulation and neurological disorders, but further investigation is needed.
- Cardiovascular Disease: Recent studies are exploring the role of TOP3A in heart health and its potential association with cardiovascular disease.
Did you know?
TOP3A is often referred to as a "housekeeping gene" because it is essential for the basic functioning of most cells.
