FOLR1 : folate receptor alpha
Description
FOLR1, or Folate Receptor 1, is a transmembrane protein crucial for folate uptake and metabolism. It binds to folate, a B vitamin essential for DNA synthesis, cell division, and various metabolic processes. FOLR1 plays a significant role in embryonic development, neural tube formation, and overall cell growth. It is highly expressed in various tissues, including the placenta, brain, and gastrointestinal tract, highlighting its essential role in multiple physiological processes.
Associated Diseases
- Neural tube defects (NTDs): FOLR1 mutations can lead to impaired folate uptake, increasing the risk of NTDs.
- Cancer: Elevated FOLR1 expression is often observed in certain cancers, such as breast, ovarian, and colorectal cancer.
- Autoimmune disorders: FOLR1 antibodies have been linked to autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus.
Did you know?
FOLR1 is a target for folate-based drugs, including methotrexate, used in cancer chemotherapy. FOLR1‘s ability to transport folate into cells makes it a crucial player in the efficacy of these treatments.
