CEP63
Description
The CEP63 (centrosomal protein 63) is a protein-coding gene located on chromosome 3.
Centrosomal protein of 63 kDa is a protein that in humans is encoded by the CEP63 gene. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined.
== Function == This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Recent computational analysis revealed pathogenic property of L61P point mutation in CEP63 protein that affected its native structural conformation.
== Interactions == CEP63 has been shown to interact with DISC1, CEP152 and CDK1.
== References ==
== External links == Human CEP63 genome location and CEP63 gene details page in the UCSC Genome Browser.
CEP63 is essential for the proper formation of the spindle apparatus, a crucial structure during cell division. It actively participates in centriole duplication, a process where new centrioles are generated from pre-existing ones. This role likely involves interactions with other proteins like CEP152, CDK5RAP2, and WDR62, forming a complex at the centrosome. This complex further recruits CDK2, a key enzyme for centriole duplication. CEP63 has been suggested to recruit CEP152 to the centrosome, however, this function is still under investigation. It also brings CDK1 to the centrosomes. CEP63 plays a role in the cellular response to DNA damage. When DNA damage occurs, CEP63 is removed from the centrosomes, halting spindle assembly and delaying cell division, ensuring that damaged DNA is not replicated. This protein has a stabilizing effect on the FXR1 protein by preventing its degradation, an action achieved by inhibiting FXR1 ubiquitination. CEP63 interacts with multiple proteins, including CEP152, CDK1, CDK2, CDK5RAP2, WDR62, CEP90, KIAA0753/moonraker, CCDC14, and CCDC57. The interaction with CCDC57 is required for their localization to the proximal end of centrioles. The interaction with FXR1 promotes FXR1 stabilization. Furthermore, CEP63 interacts with the zika virus serine protease NS3, leading to centrosome disorganization.
CEP63 is also known as SCKL6.
