MEPE
Description
The MEPE (matrix extracellular phosphoglycoprotein) is a protein-coding gene located on chromosome 4.
Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) is a protein encoded by the MEPE gene in humans. It contains a conserved RGD motif, potentially involved in integrin recognition.
MEPE promotes renal phosphate excretion and inhibits intestinal phosphate absorption. It also promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. MEPE regulates the mineralization of the extracellular matrix of the craniofacial complex, including teeth, bone, and cartilage. It also promotes dental pulp stem cell proliferation and differentiation.
MEPE is also known as OF45.
