MEI4


Description

The MEI4 (meiotic double-stranded break formation protein 4) is a protein-coding gene located on chromosome 6.

MEI4 is crucial for the formation of DNA double-strand breaks (DSBs) in regions of unsynapsed chromosomes during meiotic recombination. This process is essential for the completion of synapsis, the pairing of homologous chromosomes. MEI4 likely achieves this function by forming a complex with IHO1 and REC114, which together activate DSB formation in these unsynapsed regions.

MEI4 is also known as -.

Associated Diseases



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