MEG3
Description
The MEG3 (maternally expressed 3) is a ncRNA gene located on chromosome 14.
MEG3 (maternally expressed 3) is a long non-coding RNA gene that is maternally expressed and imprinted. It is involved in the regulation of growth and cell proliferation and has been linked to the development of Alzheimer's disease. MEG3 is a tumor suppressor that activates the p53 pathway and inhibits cell proliferation. Its expression is lost in cancer cells. Studies suggest that an upstream intergenic differentially methylated region (IG-DMR) regulates imprinting of the region. MEG3 is also implicated in the regulation of the DLK1-GTL2 imprinted domain, which is involved in muscle development and other processes. MEG3 is thought to play a role in the development of Alzheimer's disease by triggering necroptosis.
MEG3 is also known as FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1.
Associated Diseases
- Kagami-Ogata syndrome due to paternal uniparental disomy of chromosome 14
- Temple syndrome due to paternal 14q32.2 hypomethylation
- Kagami-Ogata syndrome due to maternal 14q32.2 hypermethylation
- Kagami-Ogata syndrome due to maternal 14q32.2 microdeletion
- Temple syndrome due to paternal 14q32.2 microdeletion
- Temple syndrome due to maternal uniparental disomy of chromosome 14
