IFNL3

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Description

The IFNL3 gene, also known as IL28B, plays a crucial role in the immune response to viral infections, particularly hepatitis C virus (HCV). It encodes a type III interferon, a signaling molecule that activates antiviral pathways within cells. Variations in the IFNL3 gene have been linked to differences in HCV treatment response and susceptibility to other viral infections.

Associated Diseases

• Hepatitis C Virus (HCV) Infection
• Chronic Hepatitis B Virus (HBV) Infection
• HIV Infection
• Influenza
• Dengue Fever
• COVID-19

Did you know?

Genetic variations in the IFNL3 gene are one of the strongest predictors of response to pegylated interferon and ribavirin therapy for chronic HCV infection.