DPYD

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Description

The dihydropyrimidine dehydrogenase (DPYD) gene plays a crucial role in the metabolism of fluoropyrimidine drugs, which are widely used in cancer chemotherapy. It encodes the DPYD enzyme, responsible for breaking down 5-fluorouracil (5-FU) and other fluoropyrimidines. Variations in the DPYD gene can lead to altered enzyme activity, affecting how effectively these drugs are metabolized. This can result in significant variations in drug efficacy and toxicity, making DPYD testing increasingly important in personalized medicine.

Associated Diseases

• Fluoropyrimidine-induced toxicity
• Cancer
• Dihydropyrimidine dehydrogenase deficiency

Did you know?

DPYD gene mutations are one of the most common causes of severe drug toxicity in cancer chemotherapy.