DPYD

The DPYD gene encodes an enzyme called dihydropyrimidine dehydrogenase (DPD). Reduced DPD activity affects the metabolism of certain chemotherapy drugs,

Associated Diseases

Fluoropyrimidine Metabolism, Dihydropyrimidine Dehydrogenase Deficiency

Did you Know

• The DPYD gene provides instructions for creating the DPD enzyme.
• DPD is involved in the breakdown of molecules called uracil and thymine when they are no longer needed.
• Uracil and thymine are pyrimidines, which are essential components of nucleotides—building blocks of DNA, RNA, and cellular energy sources like ATP and GTP.