CYP3A5
Description
CYP3A5 is a gene responsible for encoding a cytochrome P450 enzyme, a crucial protein involved in drug metabolism. It primarily functions in the liver and intestines, breaking down various medications and other substances. CYP3A5 exhibits significant variability in its expression, influenced by genetic factors and environmental exposures. This variability plays a vital role in determining individual responses to medications, influencing drug efficacy and adverse effects.
Associated Diseases
- Autoimmune diseases like Systemic Lupus Erythematosus (SLE)
- Cardiovascular diseases like hypertension and coronary artery disease
- Kidney diseases like chronic kidney disease
- Cancer, particularly breast and prostate cancer
- Inflammatory bowel diseases like Crohn‘s disease and ulcerative colitis
- Metabolic disorders like obesity and diabetes
Did you know?
CYP3A5 is highly polymorphic, meaning it has many variations within the population. These variations can impact enzyme activity, leading to different drug responses.
