CYP3A4

Description

CYP3A4, a member of the cytochrome P450 enzyme family, is a crucial enzyme responsible for metabolizing over 50% of drugs in the human body. Located primarily in the liver, it plays a vital role in breaking down various substances, including medications, toxins, and steroid hormones. This enzyme exhibits a high degree of substrate diversity and can metabolize a wide range of compounds. CYP3A4‘s activity is influenced by various factors, including genetics, age, gender, and the presence of other drugs. Understanding this enzyme‘s role is essential for drug development, personalized medicine, and optimizing patient treatment.

Associated Diseases

• Liver diseases (cirrhosis, hepatitis)
• Cardiovascular diseases (hypertension, heart failure)
• Cancer (breast, prostate, colon)
• Neurological disorders (Alzheimer‘s disease, Parkinson‘s disease)
• Infectious diseases (HIV/AIDS, tuberculosis)
• Autoimmune disorders (rheumatoid arthritis, lupus)

Did you know?

CYP3A4 is known to be highly polymorphic, meaning there are variations in its gene sequence among individuals. These variations can affect the enzyme‘s activity and influence drug metabolism.