CYP2R1 belongs to the CYP2 family of cytochrome P450 proteins, which are frequently involved in the metabolism of foreign compounds. CYP2R1 is a vitamin D 25-hydroxylase (Cheng et al., 2003). 

The synthesis of bioactive vitamin D requires hydroxylation at the 25 and 1-alpha positions by cytochrome P450 enzymes in the liver and kidney, respectively. 

Associated Diseases

Vitamin D Metabolism, Rickets

Did you know

  • CYP2R1 is the principal vitamin D 25-hydroxylase.
  • It plays a crucial role in converting vitamin D to its active form.
  • Specifically, it catalyzes the formation of 25-hydroxyvitamin D, also known as calcidiol.

Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.