CYP2R1

CYP2R1 belongs to the CYP2 family of cytochrome P450 proteins, which are frequently involved in the metabolism of foreign compounds. CYP2R1 is a vitamin D 25-hydroxylase (Cheng et al., 2003). 

The synthesis of bioactive vitamin D requires hydroxylation at the 25 and 1-alpha positions by cytochrome P450 enzymes in the liver and kidney, respectively. 

Associated Diseases

Vitamin D Metabolism, Rickets

Did you know

• CYP2R1 is the principal vitamin D 25-hydroxylase.
• It plays a crucial role in converting vitamin D to its active form.
• Specifically, it catalyzes the formation of 25-hydroxyvitamin D, also known as calcidiol.