CYP2D6
Description
The CYP2D6 gene is a crucial player in the metabolism of various drugs, affecting their effectiveness and side effects. This gene codes for a cytochrome P450 enzyme, specifically CYP2D6, found primarily in the liver. CYP2D6 is responsible for breaking down a wide range of medications, including antidepressants, antipsychotics, opioids, and beta-blockers. Its activity can vary significantly among individuals, leading to different drug responses and potential adverse effects.
Associated Diseases
- Poor Metabolizer Phenotype: Individuals with low CYP2D6 activity may experience increased drug levels, leading to side effects and potentially toxic outcomes.
- Ultrarapid Metabolizer Phenotype: Individuals with high CYP2D6 activity may metabolize drugs too quickly, leading to decreased efficacy and requiring higher doses.
- Pharmacogenetic Variability: Variations in CYP2D6 activity can contribute to individual differences in drug response, highlighting the importance of personalized medicine.
- Cardiovascular Diseases: Genetic variations in CYP2D6 have been linked to altered metabolism of cardiovascular drugs, potentially impacting their effectiveness and safety.
Did you know?
The CYP2D6 gene is highly polymorphic, meaning it has many variations. This variability accounts for a significant portion of the differences in drug response observed among individuals.
