CYP1A2

The CYP1A2 gene provides instructions for making an enzyme called cytochrome P450 1A2, which is primarily found in the liver. This enzyme plays a crucial role in the metabolism of various substances, including medications and toxins. It helps break down these substances into forms that are easier for the body to eliminate.

Cytochrome P450 enzyme involved in drug metabolism and caffeine sensitivity. 

Associated Diseases

Associated Diseases

Variations in the CYP1A2 gene can affect how quickly or slowly a person metabolizes certain medications. This can lead to altered drug responses, increased risk of side effects, or reduced effectiveness. While there are no specific diseases directly caused by variations in the CYP1A2 gene, its altered activity has been associated with an increased risk of:

• Cancer: Some studies have suggested a potential link between certain CYP1A2 gene variations and an increased risk of certain types of cancer, such as lung cancer and breast cancer. However, more research is needed to confirm these associations.

• Parkinson‘s Disease: Altered CYP1A2 activity has been observed in some individuals with Parkinson‘s disease, although the exact relationship is not fully understood.

Associated Medicines

Many medications are metabolized by the CYP1A2 enzyme. Some examples include:

• Antidepressants:Certain antidepressants, such as fluvoxamine and duloxetine, are primarily metabolized by CYP1A2.
• Antipsychotics:Clozapine and olanzapine are antipsychotic medications that are significantly affected by CYP1A2 activity.
• Caffeine:CYP1A2 is the primary enzyme responsible for the metabolism of caffeine.
• Theophylline:Theophylline, a medication used to treat respiratory conditions, is also metabolized by CYP1A2.

Did you know

Individuals carrying the CYP1A2*1C allele are considered “slow” caffeine metabolizers, while those with the variant CYP1A2*1F are “fast” caffeine metabolizers