MB21D1
Megakaryoblastic Leukemia (M21d1): A Comprehensive Guide
Description
Megakaryoblastic leukemia (M21d1), a rare and aggressive subtype of acute myeloid leukemia (AML), is characterized by the uncontrolled proliferation and accumulation of immature megakaryoblasts, which are precursors to platelets. In M21d1, these megakaryoblasts exhibit abnormal morphology and fail to mature into functional platelets, leading to severe bleeding disorders and other complications.
Associated Diseases
M21d1 is often associated with certain genetic mutations, particularly mutations in the following genes:
- CBFA2T3-GLIS2: This fusion gene is found in approximately 20% of M21d1 cases.
- RBM15-MKL1: Another fusion gene found in around 10% of cases.
- ETV6-RUNX1: A translocation involving these genes is associated with a more aggressive form of M21d1.
Did you Know ?
M21d1 accounts for approximately 1% of all AML cases, making it a relatively rare subtype. However, its incidence is higher in children and young adults compared to older adults.
