MAP7
Description
The MAP7 (microtubule associated protein 7) is a protein-coding gene located on chromosome 6.
Ensconsin is a protein that in humans is encoded by the MAP7 gene. The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. In addition, MAPs also play a role in regulating cellular transport. MAP7 is a necessary cofactor to activate and subsequently transport cargos by Kinesin-1. MAP7's effect on Dynein is still debated. MAP7 has been shown to interact with TRPV4.
MAP7 is a microtubule-stabilizing protein that is crucial for the rearrangement of microtubules during epithelial cell polarization and differentiation. MAP7 binds to microtubules in a dynamic fashion and may be involved in the formation of intercellular contacts. Colocalization with TRPV4 leads to the redistribution of TRPV4 towards the membrane and may link cytoskeletal microfilaments.
MAP7 is also known as E-MAP-115, EMAP115.
Associated Diseases
- multiple sclerosis
- Alzheimer disease
- lysosomal storage disease
- Parkinson disease
- partial chromosome Y deletion
- spermatogenic failures 50
- spermatogenic failure 25
- isochromosomy Yp
- spermatogenic failure, X-linked, 2
- spermatogenic failure 63
- isochromosomy Yq
- isolated congenital hypogonadotropic hypogonadism
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 44
- 46,XX testicular disorder of sex development
- persistent Mullerian duct syndrome
- congenital bilateral absence of vas deferens
