MAP4K5
Description
The MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5) is a protein-coding gene located on chromosome 14.
Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5) is an enzyme encoded by the MAP4K5 gene in humans. It belongs to the serine/threonine protein kinase family and shares high similarity with the yeast SPS1/STE20 kinase. Yeast SPS1/STE20 is involved in the initial stages of the MAP kinase signaling cascades, which are crucial for yeast pheromone response. Studies have shown that MAP4K5 can activate Jun kinase in mammalian cells, suggesting a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. MAP4K5 has been shown to interact with CRKL and TRAF2.
MAP4K5 may be involved in responding to environmental stress and appears to function upstream of the JUN N-terminal pathway.
MAP4K5 is also known as GCKR, KHS, KHS1, MAPKKKK5.
