MAP3K4
Description
The MAP3K4 (mitogen-activated protein kinase kinase kinase 4) is a protein-coding gene located on chromosome 6.
Mitogen-activated protein kinase kinase kinase 4 (MAP3K4) is an enzyme encoded by the MAP3K4 gene in humans. It is a key component of mitogen-activated protein kinase (MAPK) signaling pathways, which play crucial roles in cellular processes like growth, differentiation, and stress responses. MAP3K4 specifically activates the CSBP2 (p38α) and JNK MAPK pathways, which are involved in responses to environmental stresses like osmotic shock, UV irradiation, and inflammation. It does not activate the ERK pathway, which is primarily involved in cell growth and proliferation. MAP3K4 acts as a kinase, phosphorylating and activating downstream kinases like PRKMK6 (MKK6) and SERK1 (MKK4). These kinases then activate the CSBP2 (p38α) and JNK pathways, respectively. Two distinct isoforms of MAP3K4 have been identified, generated by alternative splicing of the MAP3K4 gene.
MAP3K4, also known as MEKK4 or MTK1, is a component of a protein kinase signal transduction cascade. It activates the CSBP2, p38, and JNK MAPK pathways, but not the ERK pathway. Specifically, MEKK4 phosphorylates and activates MAP2K4 and MAP2K6, which are kinases upstream of the p38 and JNK pathways, respectively.
MAP3K4 is also known as MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412.
Associated Diseases
- 46,XY complete gonadal dysgenesis
- 46,XY partial gonadal dysgenesis
- autosomal recessive spondylocostal dysostosis
- 46,XX testicular disorder of sex development
- autosomal dominant spondylocostal dysostosis
- spondylometaphyseal dysplasia, A4 type
- spina bifida-hypospadias syndrome
- Acropectorovertebral dysplasia
- diaphanospondylodysostosis
- isolated hemihyperplasia
- caudal duplication
