MAGEA4
Description
The MAGEA4 (MAGE family member A4) is a protein-coding gene located on chromosome X.
MAGEA4 is a human gene that encodes a protein known as Melanoma-associated antigen 4. It belongs to the MAGEA gene family, which encodes proteins with significant sequence similarities. The MAGEA genes have diverse promoters and first exons, suggesting that they may function under different transcriptional controls. MAGEA genes are located on chromosome Xq28 and have been linked to hereditary disorders like dyskeratosis congenita. Several variants of the gene encode the same protein. MAGE4 expression in salivary gland carcinomas correlates with lower-grade histology, reduced metastasis, and better survival outcomes. Although widely expressed by many tumors, MAGEA4 is almost universally found in synovial sarcomas. Currently, clinical trials are underway (as of June 2021) to explore targeted treatments using genetically modified autologous T cells against MAGEA4.
MAGEA4 regulates cell proliferation by inhibiting cell cycle arrest at the G1 phase and negatively regulates p53-mediated apoptosis.
MAGEA4 is also known as CT1.4, MAGE-41, MAGE-X2, MAGE4, MAGE4A, MAGE4B.
Associated Diseases
- cancer
- skin squamous cell carcinoma
- epithelial skin neoplasm
- breast cancer
- salivary gland carcinoma
- ovarian serous tumor
- telomere syndrome
