LYVE1
Description
The LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1) is a protein-coding gene located on chromosome 11.
LYVE1, also known as XLKD1, is a protein that binds to hyaluronic acid (HA). It is encoded by the LYVE1 gene and is a type I integral membrane glycoprotein. LYVE1 acts as a receptor, binding to both soluble and immobilized HA. It may play a role in transporting HA within the lymphatic system and is involved in tumor metastasis. LYVE1 is found on the surface of lymphatic endothelial cells and can be used to identify these cells for research purposes. While the exact function of LYVE1 is still being studied, its evolutionary conservation suggests its importance. While LYVE1 is mainly found in lymph vessels, it is also present in liver blood sinusoids, embryonic blood vessels, and a subset of macrophages. LYVE1-positive macrophages are found in the meninges of rats and are both lymphatic and alymphatic.
LYVE1 acts as a transporter, moving molecules between intracellular organelles and the cell surface. It plays a role in regulating cell growth by interacting with growth factors. LYVE1 may be involved in transporting hyaluronic acid (HA) within lymphatic endothelial cells, either breaking it down or moving it to lymphatic vessels for later degradation. Additionally, it binds to HA on leukocytes, aiding their adhesion and movement through lymphatic endothelium.
LYVE1 is also known as CRSBP-1, HAR, LYVE-1, XLKD1.
