LY6H
Description
The LY6H (lymphocyte antigen 6 family member H) is a protein-coding gene located on chromosome 8.
LY6H is believed to modulate the activity of nicotinic acetylcholine receptors (nAChRs). In vitro studies have shown that LY6H inhibits the maximum response of alpha-3:beta-4-containing nAChRs. It may play a role in the intracellular trafficking of alpha-7-containing nAChRs and potentially inhibit their expression on the cell surface. LY6H appears to suppress alpha-7/CHRNA7 signaling in hippocampal neurons. {ECO:0000250|UniProtKB:F1LNW6, ECO:0000250|UniProtKB:Q9WUC3}
LY6H is also known as NMLY6.
