LY6E

Description

The LY6E (lymphocyte antigen 6 family member E) is a protein-coding gene located on chromosome 8.

LY6E, also known as Lymphocyte antigen 6E, is a protein encoded by the LY6E gene in humans. Elevated LY6E expression has been linked to poor survival outcomes in various cancers, based on a comprehensive analysis of over 130 published clinical studies examining gene expression in cancer tissues and adjacent normal tissues. LY6E is associated with drug resistance and tumor immune evasion in breast cancer. Further research is needed to validate LY6E for translational research.

LY6E is a GPI-anchored cell surface protein that plays a crucial role in regulating T-lymphocyte proliferation, differentiation, and activation. It modulates T-cell receptor (TCR) signaling by interacting with CD3Z/CD247 at the plasma membrane, influencing CD3Z/CD247 phosphorylation. LY6E also acts as a barrier against human coronaviruses, including SARS-CoV, MERS-CoV, and SARS-CoV-2, by blocking spike protein-mediated membrane fusion. Moreover, LY6E is essential for placenta formation, serving as the primary receptor for syncytin-A (SynA). This interaction facilitates the fusion of syncytiotrophoblast layer I (SynT-I) and ensures proper vascular development in both the fetus and mother within the placenta. Additionally, LY6E may modulate the activity of nicotinic acetylcholine receptors (nAChRs).

LY6E is also known as RIG-E, RIGE, SCA-2, SCA2, TSA-1.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing