LRRC75A-AS1
lrrc75a-as1: A Long Non-Coding RNA with Potential Roles in Human Diseases
Description
lncRNA lrrc75a-as1 is a long non-coding RNA (lncRNA) located on chromosome 12q24.12. It is transcribed antisense to the protein-coding gene lrrc75a, which encodes a leucine-rich repeat containing protein involved in membrane trafficking. lncRNAs are RNA molecules that are not translated into proteins but play regulatory roles in gene expression, chromatin architecture, and various cellular processes.
Associated Diseases
lncRNA lrrc75a-as1 has been implicated in the pathogenesis of several human diseases, including:
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Alzheimer's Disease: Studies have shown that lrrc75a-as1 levels are significantly increased in the brains of Alzheimer's disease patients and that it may contribute to neuronal dysfunction and neurodegeneration.
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Parkinson's Disease: lrrc75a-as1 has also been associated with Parkinson's disease, a neurodegenerative disorder characterized by tremors, rigidity, and impaired movement. Researchers have identified variations in the lrrc75a-as1 gene that may increase the risk of developing Parkinson's disease.
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Amyotrophic Lateral Sclerosis (ALS): lrrc75a-as1 has been found to be downregulated in ALS, a fatal neurodegenerative disorder that affects motor neurons. This suggests that lrrc75a-as1 may play a protective role in ALS.
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Osteoarthritis: lrrc75a-as1 has been identified as a potential biomarker for osteoarthritis, a degenerative joint disease characterized by pain and loss of mobility. Studies have shown that lrrc75a-as1 levels are increased in the synovial fluid of osteoarthritis patients.
Did you Know ?
- According to a study published in the journal "Neurology," individuals carrying a specific variation in the lrrc75a-as1 gene have a 30% higher risk of developing Parkinson's disease.
