LRRC38
Description
The LRRC38 (leucine rich repeat containing 38) is a protein-coding gene located on chromosome 1.
LRRC38 acts as an auxiliary subunit for the BK alpha channel, a type of potassium channel. It influences the channel's opening and closing behavior by shifting its activation voltage towards more negative values, even in the absence of calcium. This effect alters the channel's response to electrical signals.
LRRC38 is also known as -.
Associated Diseases
- exudative vitreoretinopathy 2, X-linked
- 46,XX testicular disorder of sex development
- 46,XX ovotesticular disorder of sex development
- 46,XY complete gonadal dysgenesis
- gonadoblastoma
- cancer
