LRRC19
Description
The LRRC19 (leucine rich repeat containing 19) is a protein-coding gene located on chromosome 9.
LRRC19 is a pathogen-recognition receptor that activates the TRAF2- and TRAF6 NF-kappa-B signaling pathways, leading to the production of pro-inflammatory cytokines. It plays a role in protecting the kidney from uropathogenic bacterial infections by stimulating the production of cytokines, chemokines, and antimicrobial substances. In the gut, LRRC19 is involved in host-microbiota interactions, promoting immune cell recruitment and intestinal inflammation.
LRRC19 is also known as -.
Associated Diseases
- isolated agammaglobulinemia
- common variable immunodeficiency
- mannose-binding lectin deficiency
- recurrent Neisseria infections due to factor D deficiency
- immune deficiency, familial variable
- hyper-IgM syndrome type 2
- immunodeficiency, common variable, 4
- type II complement component 8 deficiency
- immunodeficiency 28
- immunodeficiency due to ficolin3 deficiency
