LRRC17
Description
The LRRC17 (leucine rich repeat containing 17) is a protein-coding gene located on chromosome 7.
Leucine-rich repeat-containing protein 17 is a protein produced by the LRRC17 gene in humans. It is involved in bone homeostasis and acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors. You can find more information about this gene at the UCSC Genome Browser.
LRRC17 plays a crucial role in maintaining bone health. It acts as a brake on the formation of osteoclasts, which are cells that break down bone. This regulation occurs by inhibiting the differentiation of osteoclast precursors, cells that have the potential to become osteoclasts, in response to RANKL, a signaling molecule that promotes osteoclast development.
LRRC17 is also known as P37NB.
Associated Diseases
- type 2 diabetes mellitus
- hemolytic anemia due to glucophosphate isomerase deficiency
- ichthyosis-hepatosplenomegaly-cerebellar degeneration syndrome
- congenital dyserythropoietic anemia type 2
- idiopathic hypereosinophilic syndrome
- progressive familial intrahepatic cholestasis type 3
- Senior-Boichis syndrome
- non-spherocytic hemolytic anemia due to hexokinase deficiency
