LRRC15
Description
The LRRC15 (leucine rich repeat containing 15) is a protein-coding gene located on chromosome 3.
LRRC15 is a cell membrane-expressed protein encoded by the LRRC15 gene, located on chromosome 3 at 3q29. It belongs to the LRR superfamily, involved in cell–cell and cell–ECM interactions. Preliminary evidence suggests that its expression may be related to the severity of COVID-19 and that it acts as an inhibitory accessory factor for SARS-CoV-2 cell entry. LRRC15 lacks obvious intracellular domains and displays a restricted expression pattern, being found in innate immune barriers like the placenta, skin, activated fibroblasts in wounds, and lymphoid tissues. This suggests a potential role in innate immunity. LRRC15 is also aberrantly expressed in cancer, particularly in CAFs within the stroma of solid tumors and directly expressed in mesenchymal tumors such as glioblastoma, sarcomas, and melanoma.
Modulates the ability of SARS-CoV-2 to infect host cells by interacting with the spike protein. It does not act as a SARS-CoV-2 entry receptor but sequesters virions and antagonizes SARS-CoV-2 infection of ACE2(+) cells when expressed on nearby cells.
LRRC15 is also known as LIB.
