LPPR4


Lipoprotein(a) [Lp(a)] and Cardiovascular Disease: An In-Depth Analysis

Description

Lipoprotein(a) [Lp(a)] is a complex lipoprotein composed of an oxidized low-density lipoprotein (LDL) particle linked to a glycoprotein called apolipoprotein(a) [apo(a)]. It is a unique apolipoprotein among lipoproteins, characterized by its size and high molecular weight. Lp(a) levels in the blood are primarily determined by genetic factors and can vary significantly among individuals.

Associated Diseases

Elevated Lp(a) levels have been strongly associated with an increased risk of cardiovascular disease (CVD), particularly coronary heart disease (CHD). Studies have consistently shown a positive correlation between Lp(a) levels and the occurrence of myocardial infarction (heart attack), stroke, and other CVD events. This association is independent of traditional risk factors such as cholesterol levels, blood pressure, and smoking.

Did you Know ?

Approximately 20-30% of the population has elevated Lp(a) levels, which is considered a major genetic risk factor for CVD. Individuals with the highest Lp(a) levels have a significantly higher risk of developing CVD compared to those with lower levels.



Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.