LPPR4
Lipoprotein(a) [Lp(a)] and Cardiovascular Disease: An In-Depth Analysis
Description
Lipoprotein(a) [Lp(a)] is a complex lipoprotein composed of an oxidized low-density lipoprotein (LDL) particle linked to a glycoprotein called apolipoprotein(a) [apo(a)]. It is a unique apolipoprotein among lipoproteins, characterized by its size and high molecular weight. Lp(a) levels in the blood are primarily determined by genetic factors and can vary significantly among individuals.
Associated Diseases
Elevated Lp(a) levels have been strongly associated with an increased risk of cardiovascular disease (CVD), particularly coronary heart disease (CHD). Studies have consistently shown a positive correlation between Lp(a) levels and the occurrence of myocardial infarction (heart attack), stroke, and other CVD events. This association is independent of traditional risk factors such as cholesterol levels, blood pressure, and smoking.
Did you Know ?
Approximately 20-30% of the population has elevated Lp(a) levels, which is considered a major genetic risk factor for CVD. Individuals with the highest Lp(a) levels have a significantly higher risk of developing CVD compared to those with lower levels.