LPO
Description
The LPO (lactoperoxidase) is a protein-coding gene located on chromosome 17.
LPO may refer to: Lactoperoxidase (LPO), also known as Salivary peroxidase.
Lactoperoxidase (LPO) is a heme-containing oxidoreductase that catalyzes the conversion of thiocyanate (SCN-) into the antimicrobial agent hypothiocyanous acid (OSCN-) in the presence of hydrogen peroxide (H2O2). It also converts iodide (I-) into hypoiodite (IO-) in the presence of H2O2. LPO is responsible for inactivating a wide range of microorganisms, making it a crucial component of the host defense mechanism. It exhibits antibacterial properties against Pseudomonas aeruginosa, Burkholderia cepacia, and Haemophilus influenzae. LPO is found in mammary and salivary gland secretions and contributes to airway host defense against infection. Additionally, LPO may help maintain appropriate cellular levels of H2O2, protecting cells from H2O2-induced injuries and inflammation.
LPO is also known as SPO.
Associated Diseases
- Meckel syndrome
- Joubert syndrome
- Bardet-Biedl syndrome
- early-onset non-syndromic cataract
- isolated ectopia lentis
- hereditary hyperferritinemia with congenital cataracts
- cataract 13 with adult I phenotype
- cataract 38
- cataract
- Lisch epithelial corneal dystrophy
- Schnyder corneal dystrophy
