CHRNA3

Nicotinic acetylcholine receptor subunit associated with nicotine addiction.

Associated Diseases

Nicotine Addiction, Lung Cancer

Did you know

CHRNA3 variants are associated with nicotine dependence and increased lung cancer risk. The CHRNA3 gene, located on chromosome 15q25.1, encodes the alpha-3 subunit of the nicotinic acetylcholine receptor (nAChR), a ligand-gated ion channel involved in neurotransmission. This receptor is primarily expressed in neurons of the central nervous system and plays a crucial role in mediating the effects of nicotine on neuronal function.


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