LOC494141
Loc494141: A Comprehensive Guide
Description
Loc494141, also known as the cyclin-dependent kinase 18 (CDK18), is an essential protein involved in cell cycle regulation. It belongs to the cyclin-dependent kinase family, which plays a crucial role in coordinating various cellular processes, including DNA replication, cell division, and differentiation.
CDK18 acts in conjunction with specific cyclins to form active kinase complexes that regulate the progression of the cell cycle. The activity of CDK18 is tightly controlled by various mechanisms, including phosphorylation, protein-protein interactions, and cellular localization.
Associated Diseases
Mutations or dysregulation of loc494141 have been linked to several diseases, including:
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Cancer: Aberrant CDK18 expression has been observed in various types of cancer, including breast, bladder, lung, and ovarian cancer. Overexpression of CDK18 can promote tumorigenesis by disrupting cell cycle checkpoints and leading to uncontrolled cell growth.
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Neurodegenerative Disorders: Mutations in the loc494141 gene have been associated with neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. These mutations may impair CDK18 function and contribute to neuronal dysfunction and cell death.
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Other Diseases: Dysregulation of CDK18 has also been implicated in diseases such as type 2 diabetes, obesity, and immune disorders. However, the exact role of CDK18 in these conditions is still being investigated.
Did you Know ?
According to a recent study published in the journal "Nature", the frequency of loc494141 mutations in breast cancer is approximately 10%. This statistic highlights the potential significance of CDK18 in cancer development and suggests that it may be a potential target for therapeutic interventions.
