LOC283922
Loc283922: A Gene Linked to Obesity and Metabolic Disorders
Description
Loc283922 is a gene located on chromosome 11q13.3. It encodes a protein called zinc finger protein 423 (ZNF423), which is involved in various cellular processes. ZNF423 is expressed in multiple tissues, including the brain, liver, pancreas, and adipose tissue.
Associated Diseases
Mutations in the loc283922 gene have been linked to several obesity-related disorders, including:
- Obesity: Loc283922 variants have been associated with an increased risk of obesity in both children and adults.
- Type 2 Diabetes: Studies have found an association between loc283922 mutations and an increased risk of developing type 2 diabetes.
- Metabolic Syndrome: Loc283922 variants have also been linked to metabolic syndrome, a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes.
- Non-Alcoholic Fatty Liver Disease (NAFLD): Mutations in loc283922 have been associated with an increased susceptibility to NAFLD, a condition characterized by the accumulation of fat in the liver.
Did you Know ?
According to a study published in the journal "Nature Genetics," individuals carrying certain variants in the loc283922 gene have a 2-fold higher risk of developing obesity compared to those who do not carry these variants.
