LOC105376671
Loc105376671: A Promising Therapeutic Target for Cancer and Neurodegenerative Diseases
Description
Loc105376671 is a gene that encodes a protein known as Lipocalin 2 (LCN2). LCN2 is a small, secreted protein that is involved in various cellular processes, including lipid transport, inflammation, and cell growth. It is found in a wide range of tissues, including the liver, lungs, and brain.
LCN2 has been implicated in the development and progression of several diseases, including cancer and neurodegenerative disorders. In cancer, LCN2 has been shown to promote tumor growth and metastasis by increasing cell proliferation and migration. It can also suppress the immune system, making it easier for tumors to evade detection and destruction.
In neurodegenerative diseases, LCN2 is thought to contribute to neuronal damage and inflammation. It can activate microglia, the brain's immune cells, which can lead to the release of toxic substances that damage neurons. LCN2 has also been found to promote the formation of amyloid plaques, which are a hallmark of Alzheimer's disease.
Associated Diseases
- Cancer
- Non-small cell lung cancer (NSCLC)
- Breast cancer
- Hepatocellular carcinoma (HCC)
- Neurodegenerative diseases
- Alzheimer's disease
- Parkinson's disease
- Huntington's disease
- Amyotrophic lateral sclerosis (ALS)
Did you Know ?
Studies have shown that elevated levels of LCN2 are associated with poor prognosis in several types of cancer. For example, high LCN2 expression has been linked to decreased survival in patients with NSCLC and HCC.
