LOC102724050
Description
Loc102724050 is a gene located on chromosome 10, specifically on the 10q26.13 region. It encodes a protein known as Kelch-like protein 34 (KLHL34). KLHL34 is involved in various cellular processes, including protein ubiquitination and degradation.
Associated Diseases
Mutations or dysregulation of loc102724050 have been associated with several diseases and conditions:
- Colorectal cancer: Certain variants of loc102724050 have been linked to an increased risk of colorectal cancer.
- Bladder cancer: Mutations in loc102724050 have been found in bladder cancer patients, suggesting a role in its development.
- Glioblastoma: Reduced expression of KLHL34 has been observed in glioblastoma tumors, indicating its potential involvement in brain cancer.
- Developmental disorders: Disruptions in loc102724050 function have been implicated in developmental disorders such as autism spectrum disorder and intellectual disability.
Did you Know ?
One study found that approximately 5% of colorectal cancer patients carry mutations in loc102724050. This finding highlights the gene's potential significance in the development of this common cancer.
