LOC101929058
Loc101929058: The Gene Linked to Alzheimer's and Frontotemporal Dementia
Description
Loc101929058 is a gene located on chromosome 8p21.3. This gene encodes a protein called progranulin, which plays a crucial role in various cellular processes, including cell growth, survival, and inflammation. Research has linked mutations in loc101929058 to an increased risk of developing Alzheimer's disease (AD) and frontotemporal dementia (FTD).
Associated Diseases
Alzheimer's Disease (AD)
AD is a neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes. Mutations in loc101929058 have been identified as a significant genetic risk factor for AD. Individuals with these mutations have an earlier age of onset and a more rapid progression of the disease.
Frontotemporal Dementia (FTD)
FTD is a group of neurodegenerative disorders affecting the frontal and temporal lobes of the brain. FTD leads to changes in personality, behavior, and language abilities. Mutations in loc101929058 have been linked to certain types of FTD, known as the behavioral variant, semantic dementia, and progressive aphasia.
Did you Know ?
- Approximately 1 in 10 individuals with early-onset AD (onset before 65 years) carry a mutation in loc101929058.
