LOC100507377
Loc100507377: A Comprehensive Guide
Description
Loc100507377 is a long non-coding RNA (lncRNA) that plays a crucial role in various biological processes, including cell differentiation, proliferation, and apoptosis. It is located on chromosome 19q13.41 and is composed of 1,953 nucleotides.
Associated Diseases
Loc100507377 has been implicated in the development and progression of several diseases, including:
- Cancer: Loc100507377 is overexpressed in various types of cancer, including breast, lung, and colon cancer. It promotes tumor growth, metastasis, and resistance to therapy.
- Neurodegenerative disorders: Loc100507377 is downregulated in Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). Its decreased expression contributes to neuronal dysfunction and cell death.
- Cardiovascular diseases: Loc100507377 is associated with cardiac hypertrophy, heart failure, and atherosclerosis. It affects cardiomyocyte function and promotes inflammation.
Did you Know ?
A study published in Nature Communications found that high levels of Loc100507377 in breast cancer patients were associated with a 2.5-fold increase in the risk of metastasis and a 1.8-fold increase in the risk of death compared to patients with low levels of Loc100507377.
