LOC100506747
Loc100506747: A Comprehensive Guide
Description
Loc100506747, also known as the long non-coding RNA (lncRNA) RP11-139G20.4, is a genetic element found on chromosome 11p15.5 in the human genome. LncRNAs are non-protein-coding transcripts that play crucial roles in various cellular processes. Loc100506747 has been implicated in regulating gene expression, cell proliferation, and differentiation.
Associated Diseases
Research suggests that dysregulation of Loc100506747 may contribute to several diseases, including:
- Cancers: Studies have found altered expression of Loc100506747 in various cancers, such as breast, lung, and colon cancer. Its overexpression has been associated with tumor growth, metastasis, and therapy resistance.
- Neurological Disorders: Loc100506747 has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's. Its dysfunction may disrupt neuronal function and contribute to cognitive impairment.
- Autoimmune Disorders: Loc100506747 has been implicated in autoimmune diseases such as systemic lupus erythematosus (SLE). Its involvement in immune regulation suggests a role in disease pathogenesis.
Did you Know ?
A study published in the journal Nature Genetics showed that a specific genetic variant within Loc100506747 is associated with an increased risk of breast cancer in women. The variant carriers had a 15% higher risk of developing breast cancer compared to non-carriers. This finding highlights the potential link between Loc100506747 and cancer susceptibility.
