LOC100506314
Description:
Loc100506314, also known as the long non-coding RNA (lncRNA) PVT1, is a gene located on chromosome 8q24.21. It is a large, intergenic lncRNA that plays a significant role in various biological processes, including gene regulation, cell cycle progression, and genome stability.
PVT1 is characterized by its high expression in cancer cells and its association with tumorigenesis and cancer progression. It has been implicated in several types of cancer, including breast cancer, lung cancer, colorectal cancer, and leukemia.
Associated Diseases:
PVT1 overexpression has been linked to a wide range of diseases, including:
- Cancer: PVT1 is highly expressed in various cancers, promoting tumor growth, metastasis, and resistance to treatment.
- Cardiovascular disease: PVT1 is upregulated in heart failure and atherosclerosis, contributing to cardiac dysfunction and vessel remodeling.
- Neurological disorders: Elevated PVT1 levels have been observed in Alzheimer's disease and spinal cord injury, suggesting a role in neurodegeneration.
- Metabolic disorders: PVT1 is dysregulated in obesity and diabetes, influencing glucose metabolism and insulin sensitivity.
Did you Know ?
Approximately 30% of all cancer cases are associated with PVT1 overexpression. This highlights the potential significance of targeting PVT1 for cancer therapy.
