LOC100132352
Loc100132352: An in-depth Exploration
Description
Loc100132352, also known as the long non-coding RNA (lncRNA) KCNK1-AS1, is a gene that plays a crucial role in various cellular processes. It is located on chromosome 11q13.4 and consists of 11 exons and 10 introns. The lncRNA is highly conserved across different species, suggesting its importance in maintaining biological functions.
Associated Diseases
Dysregulation of loc100132352 has been linked to several diseases, including:
- Cardiovascular diseases: Studies have shown that decreased expression of loc100132352 is associated with the development of coronary artery disease, heart failure, and hypertension.
- Neurodegenerative diseases: Alterations in loc100132352 expression have been implicated in the pathogenesis of Alzheimer's disease and Parkinson's disease.
- Cancer: Overexpression of loc100132352 has been observed in various cancers, including breast cancer, lung cancer, and liver cancer.
Did you Know ?
A study published in the journal "Nature Genetics" revealed that individuals with a specific genetic variant in loc100132352 have a significantly increased risk of developing Alzheimer's disease. This variant reduces the expression of the lncRNA, highlighting its protective role in preventing neurodegeneration.
